Columbia University Medical Center

Brain area

Brain area

Image above: Brain area outlined in white is the hippocampus; the dentate gyrus is shown in blue and the entorhinal cortex in red. Previous work, including by the laboratory of senior author Scott A. Small, MD, had shown that changes in a specific part of the brain’s hippocampus—the dentate gyrus—are associated with normal age-related memory decline in humans and other mammals. The dentate gyrus is distinct from the entorhinal cortex, the hippocampal region affected in early-stage Alzheimer’s disease. Credit: Columbia University Medical Center