Columbia University Medical Center

Berrie Prize Awarded for Insights into How the Brain Controls Hunger

Dr. Rudolph L. Leibel and Dr. Bradford L. Lowell. (Credit: Columbia University Medical Center)

Columbia University has awarded the 2017 Naomi Berrie Award for Outstanding Achievement in Diabetes Research to Bradford B. Lowell, MD, PhD, professor of medicine at Harvard Medical School and Beth Israel Deaconess Medical Center. Dr. Lowell is an innovator in creating cutting-edge genetic engineering and neuroscience techniques to study energy balance and obesity.

The award was presented to Dr. Lowell during the Frontiers in Diabetes Research Symposium on Nov. 18, in a ceremony held in the Russ Berrie Medical Science Pavilion at Columbia University Medical Center (CUMC).

The Naomi Berrie Award for Outstanding Achievement is Columbia University’s top honor for excellence in diabetes research. Dr. Lowell is the 19th winner since the award’s inception in 1999.

“Dr. Lowell has been a pioneer in developing and using modern technical approaches to gain a deeper understanding of how the brain controls food intake,” said Rudolph L. Leibel, MD, the Christopher J. Murphy Memorial Professor of Diabetes Research, co-director of the Naomi Berrie Diabetes Center, and chair of the award selection committee. “The tools he has developed have led to fundamental biological insights that could transform how we manage and treat obesity.”

Dr. Lowell and his team were among the first to establish the role of brown fat—which is abundant in newborns and burns stored energy as heat—in the regulation of body weight. In a Nature paper published in 1993, they reported on the development of a new method to study brown fat, which is difficult to investigate surgically. Dr. Lowell’s team engineered mice to have a deficiency in brown fat and showed that these mice become obese. In special lines of mice designed to regenerate the brown fat, obesity disappeared.

Harnessing technical advances in genetics and neuroscience to study the brain’s complex circuitry in real time, Dr. Lowell has also examined the neural basis of hunger. In one study, Dr. Lowell’s group used optogenetics—a method that enables genes to be switched on or off using a light source—to chart how a key gene called MC4R regulates appetite in the mammalian brain. Using this technique to switch on MC4R neurons, the researchers found that they could make transgenic mice lose their appetite.

Dr. Lowell is currently using a new precision gene-editing technique called CRISPR to create lines of mice that can express specific genes in a controlled subset of neurons. These lines will allow scientists to determine which behaviors the neurons control and ultimately map in greater detail the neural connections that control hunger and compel eating.

Dr. Lowell received his MD and PhD from Boston University’s School of Medicine, completed his bachelor’s degree in physiological psychology at the University of Massachusetts, Amherst, and has published nearly 200 scientific papers.

The Naomi Berrie Award for Outstanding Achievement in Diabetes Research was established by the Russell Berrie Foundation in 1999. The award promotes and rewards outstanding achievement in the field, while at the same time supporting the careers of promising young diabetes investigators. Each year, the recipient—a senior scientist outside of Columbia who has made major contributions to diabetes research—is given $130,000 to support a two-year research fellowship for a student or research fellow in his or her laboratory.

Naomi Berrie Fellows

The Russell Berrie Foundation program also includes an award for junior-level investigators, who are designated “Berrie Fellows in Diabetes Research.” Columbia has awarded the 2017 Berrie Fellowships to Amelia M. Douglass, PhD, and Junjie Yu, PhD.

Dr. Douglass received her PhD from the Max Planck Institute of Neurobiology in Munich, Germany, and a bachelor’s degree in developmental neurobiology from the University of Queensland in Brisbane, Australia. In the Lowell Lab, Dr. Douglass will use optogenetics, chemogenetics, cell-specific neuron-mapping techniques, and in vivo calcium-based imaging to understand the neuronal feedback and feedforward circuits associated with hunger.

Dr. Yu completed her PhD at the Institute for Nutritional Sciences, Chinese Academy of Sciences, China, and a bachelor’s degree in biological sciences at Shandong Normal University, China. Working in the lab of Utpal Pajvani, MD, PhD, Dr. Yu investigates how inhibiting components of the Notch signaling pathway can simultaneously improve obesity-induced type 2 diabetes and a liver disease called nonalcoholic steatohepatitis (NASH).

Russell Berrie Foundation Scholar

Mohsen Khosravi Maharlooei, MD, is the Russell Berrie Foundation Scholar for 2017. This award of $75,000 provides support for international scientists to work at the Naomi Berrie Diabetes Center in collaboration with Columbia scientists.

Dr. Maharlooei completed his medical degree at the Shiraz University of Medical Sciences, Iran, and holds a master’s degree in experimental medicine from the University of British Columbia in Canada. Dr. Maharlooei will work in the lab of Megan Sykes, MD, to study the diabetogenicity of different types of insulin-specific T-cell receptors.

Rudolph Leibel, Mohsen Khosravi Maharlooei, Junjie Yu, and Domenico Accili. (Credit: Columbia University Medical Center)

About:

For more information about the annual Frontiers Conference and a list of past award recipients, visit: http://www.nbdiabetes.org/frontiers.

The Naomi Berrie Diabetes Center at Columbia University Medical Center opened in 1998 to serve the 1.6 million people with diabetes in the New York area, by combining world-class diabetes research and education programs with family-oriented patient care. Founded with support from the Russell Berrie Foundation and other friends, the center is named in honor of the mother of the late Russell Berrie, founder of RUSS™ Toys. The Center’s more than 100 faculty and students conduct basic and clinical research related to the pathogenesis and treatment of all forms of diabetes and its complications. For more information, visit www.nbdiabetes.org.

Columbia University Medical Center provides international leadership in basic, preclinical, and clinical research; medical and health sciences education; and patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the College of Physicians and Surgeons, the Mailman School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. Columbia University Medical Center is home to the largest medical research enterprise in New York City and State and one of the largest faculty medical practices in the Northeast. The campus that Columbia University Medical Center shares with its hospital partner, NewYork-Presbyterian, is now called the Columbia University Irving Medical Center.  For more information, visit cumc.columbia.edu or columbiadoctors.org.