Some treatments in development hold particular promise for women. Angela Christiano, a hair geneticist and Columbia University professor of dermatology, is hoping to begin clinical trials in a year or two on a procedure in which she dissects hair-follicle stem cells, grows them in the lab until she has several million, then injects them into the scalp, where, a very small study done with a human skin model has shown, they induce new hairs.
As Dr. [Stephen] Goff and his colleagues, Michael J. Metzger at Columbia and Carol Reinish and James Sherry at Environment Canada, reported in the journal Cell, it was not a virus hopping from clam to clam but the cancer cells themselves. They may last only hours in seawater, but that is long enough to reach other clams and infect them.
Tom Maniatis, director of the Columbia University Precision Medicine Initiative, discusses the future of precision medicine as it relates to treating deadly diseases.
“The general principle is the same: in the spring, wherever you are, whenever it becomes temperate, trees start to emit their pollen,” Dr. Rachel Miller, chief of pediatric allergy, immunology and rheumatology at Columbia University Medical Center, told TIME.
Other factors that can contribute to fatigue and overuse, and then lead to injury, are year-round baseball, throwing too many pitches in a single game and throwing too many innings in a game or season, said Dr. Christopher Ahmad, the New York Yankees’ head team physician and professor of orthopedic surgery at Columbia University Medical Center in New York City.
Jeffrey Lieberman, MD, author of Shrinks: The Untold Story of Psychiatry (Little Brown and Co., 2015), is chair of psychiatry at Columbia University Columbia University Medical Center and psychiatrist in chief of the New York Presbyterian Hospital as well as the immediate past President of the American Psychiatric Association.
Guohua Li, director of Columbia University’s Center for Injury Epidemiology and Prevention, described current medical standards for airline pilots as “outdated, inadequate and inconsistent,” especially regarding mental health assessment. “These standards need to be updated, strengthened and made internationally compatible.”
The documentary is based on the 2010 Pulitzer Prize winning book “The Emperor Of All Maladies: A Biography Of Cancer” by our guest Siddhartha Mukherjee. As an oncologist immersed in the daily care of patients, he wanted to pull back and research the history of cancer to better understand the illness he was confronting and treating. Dr. Mukherjee is a cancer physician and researcher and an assistant professor of medicine at Columbia University. Terry Gross interviewed him when his book was published in 2010.
Dr. Burton Edelstein, chair of the Section of Population Oral Health at Columbia University College of Dental Medicine in New York City, agreed that more research is needed on xylitol’s potential to prevent cavities. He cautioned that lack of evidence is not evidence against xylitol, however. For example, Edelstein and colleagues estimate in a new report published in the Journal of the American Dental Association that money might be saved by giving mothers xylitol products because they cut the transmission of bacteria that cause tooth decay from mother to child.
“His attitude toward this kind of food is a little worrisome,” said David Seres, MD, director of medical nutrition at the Columbia University Medical Center in New York, adding that he thinks such investments send the worst kind of message to America. “He is not what I would call an ideal role model in eating and his attitude toward nutrition in general.”
While it’s typically difficult to draw conclusions when looking for deaths among a group of people, Dr. Andrew E. Moran from Columbia University Medical Center said it’s appropriate for this trial. “Because the survival is so poor in these very ill people, it’s not unreasonable to recruit a fairly small sample size because the probability of adverse events and death is very high in these patients,” said Moran, who was not involved with the new study.
Though celiac disease is four to five times more common now than 50 years ago, only about 1 percent of the world’s population is believed to suffer from it, and just a fraction of those have been diagnosed. Dr. Peter Green, director of the Celiac Disease Center at Columbia University Medical Center, says more than 80 percent of people with celiac disease don’t realize they have it.
“When you look at the key outcomes of death and stroke, there’s been a significant reduction in both those outcomes with this generation of the device,” said [Susheel] Kodali, director of the Heart Valve Center at New York Presbyterian/Columbia University Medical Center in New York. “This is the device people are waiting for.”
Jennifer S. Hirsch is a Professor of Sociomedical Sciences at Columbia’s Mailman School of Public Health.
Abdul El-Sayed, a physician and epidemiologist, and assistant professor of epidemiology at Columbia University, is a Soros fellow. 15 other Soros fellows signed the op-ed.
“The fact that the Nobel committee [honored] malaria cures and lobotomies underscores the desperation for any form of treatment for mental illness,” Jeffrey Lieberman writes in his new book, “Shrinks.”
“Autopsies in general are on the downswing, but brain autopsy is increasing. People are scared and want to do something,” says Arlene Lawton, a registered nurse who runs the brain donation program at Columbia University Medical Center in New York. She says families often call about donating when a loved one is in the terminal stages, which is too late. Patients must be able to undergo memory and neurological tests while still living, she says, so researchers can correlate their symptoms with brain changes after death.
While empathy courses are rarely required in medical training, interest in them is growing, experts say, and programs are underway at Jefferson Medical College and at Columbia University School of Medicine. Columbia has pioneered a program in narrative medicine, which emphasizes the importance of understanding patients’ life stories in providing compassionate care.
Teeth are dynamic. If they demineralize at a quicker rate than they remineralize, you get a cavity, said Dr. Burton Edelstein, a professor of dentistry and health policy at Columbia University. Conversely, it is possible to remineralize a decaying tooth by arresting the disease process, he said.
“There are biological markers that can be detected in the blood soon after the onset of the disease, and this has very important diagnostic implications,” said Dr. Mady Hornig, an associate professor of epidemiology at Columbia University and lead author of the new study.
“What color is this dress?” sparks fierce debate on Twitter and in offices. Columbia University’s Dr. Kenneth Miller explains why we see different colors.
Dr. [Craig] Spencer, 33, an attending physician in the emergency department of NewYork-Presbyterian/Columbia University Medical Center, wrote that when he returned to New York from Guinea, where he had been treating Ebola patients with Doctors Without Borders, “the suffering I’d seen, combined with exhaustion, made me feel depressed for the first time in my life.”
“We did not see a significant effect of financial incentives,” said Dr. Wafaa M. El-Sadr, an AIDS expert at Columbia University and the lead investigator. But, she said, there is “promise for using such incentives in a targeted manner.”
When viruses mutate, scientists try to stay one step ahead. Columbia University virologist Vincent Racaniello explains the different ways that viruses like Enterovirus D68 can change.
If you look very carefully at the C-curved squiggle taking shape on a 3-D printer at Columbia University Medical Center, you just might spot the future of knee repair. Layer by layer, the machine’s tiny needle squirts out a bead of white polymer, matching a virtual blueprint of a meniscus—the semicircular band of tough, fibrous cartilage that serves as the knee’s shock absorber. A bioprinter in the laboratory of Jeremy Mao can churn out three menisci in just under 16 minutes.
“People with complicated grief often feel shocked, stunned or emotionally numb, and they may become estranged from others because of the belief that happiness is inextricably tied to the person who died,” wrote Dr. [Katherine] Shear, of the Columbia University School of Social Work and College of Physicians and Surgeons.
“So many kids never pick up the pills, or pick up the pills and don’t take them right,” said Melanie Gold, medical director of Columbia University’s School-Based Health Centers. “Clearly, an IUD is a better choice.”
Herbert D. Kleber, a psychiatrist and the director of the substance-abuse division at the Columbia University–N.Y. State Psychiatric Institute, who is one of the nation’s leading experts on drug abuse, struck a cautionary note. “The whole area of research is fascinating,” he said. “But it’s important to remember that the sample sizes are small.”
“I don’t think the results are necessarily surprising, they just highlight that there is very little publicly reported hospital data to help guide cancer patients in decision making,” said lead author Dr. Jason D. Wright of the Columbia University College of Physicians and Surgeons in New York.
Robert Klitzman is a professor and director of the Bioethics Masters Program at Columbia and author of “Am I My Genes?: Confronting Fate & Family Secrets in the Age of Genetic Testing” and “The Ethics Police?: The Struggle to Make Human Research Safe.
Dr. David S. Seres is director of medical nutrition and associate professor of medicine in the Institute of Human Nutrition at Columbia University Medical Center. He is a public voice fellow with the Op-Ed Project. The opinions expressed in this commentary are solely those of the author.
Critics of this procedure point to testing on mice and flies that didn’t turn out well—a possible sign that the technology scrambles important communication between the mitochondrial and the nucleus. However, those results aren’t necessarily that instructive. Both creatures used in the testing are already heavily inbred, according to Columbia University’s Dr. Robert Klitzman and Dr. Mark Sauer, and University of Oxford’s Mark Toynbee, in a recent article.
Unlike most parts of the brain, the SFO lies outside the blood-brain barrier, meaning it receives significant blood flow. Biologists at Columbia University wondered if that might mean the SFO can determine when hydration is required.
“It’s not the virus but how the host controls it that we need to be able to mimic,” says Dr. Magdalena Sobieszczyk, a researcher with the HIV/AIDS Research Program at Columbia University Medical Center in New York.
As the measles outbreak that started in Southern California continues to spread, Stephen Morse, epidemiologist from the Mailman School of Public Health at Columbia University, explains why herd immunity is so necessary to prevent a serious outbreak, what the anti-vaccine movement has to do with it, and takes your questions.
One matter to be worked out for a megabiobank is which cohorts to include, says human geneticist David Goldstein of Columbia University, a member of the 2011 NRC panel. For example, “you absolutely must have recontactability,” or permission from patients to be called and asked to come into a clinic for further exams and tests.
In a study published Monday in the journal Nature, scientists at Columbia University revealed the on/off switches for regulating thirst in the brains of mice. The scientists isolated two sets of neurons in the brain’s subfornical organ (SFO) — CAMK11, which signals thirst, and VGAT, that erases it — and were able to trigger both.
By directing pulses of light onto specific regions of the brain, researchers from Columbia University Medical Center induced feelings of extreme thirst in perfectly well hydrated mice — causing them to drink the equivalent of seven pints of water for a human.
The ratio of siblings with autism who have a common genetic basis for the disorder versus those who do not — now 30 percent to 70 percent — may be less lopsided as researchers analyze more such families, some experts said. The study “used a quite liberal approach for variants relevant to autism and the finding, while solid, may be less general than implied,” said Dr. David B. Goldstein, director of the Institute for Genomic Medicine at Columbia University.
Tuesday’s benefit for Brecker – the first – raised money to assist two doctors working at Columbia University Medical Center and fighting to cure MDS.
Around the world, the incidence of celiac disease is increasing, but researchers still don’t know why, said Dr. Peter Green, director of the Celiac Disease Center at Columbia University. “We have to address the reason,” said Green, who was not involved with the new study. He also said the new study, with the support of previous research, does not suggest that people need to follow any specific recommendation about gluten introduction.
Researchers at Columbia University Medical Center in New York identified these master cells in the marrow. When grown in the lab and transplanted back into a fracture site in mice, they helped repair the broken bones. Siddhartha Mukherjee, the study’s senior author, said similar stem cells exist in the human skeletal system. “The real provocative experiment or the provocative idea is being able to do this in humans — being able to extract out these stem cells from humans and being able to put them back in to repair complex fracture defects or osteoarthritis defects,” said Mukherjee.
“The idea of predicting infectious disease is relatively new. It’s not like weather predictions,” says Jeffrey Shaman, who despite the novelty of the field has been posting forecasts of the number of Ebola cases in Guinea, Sierra Leone and Liberia since September. Shaman is an associate professor at Mailman School of Public Health at Columbia University in New York. He says that the main challenge in creating models to predict the direction of the Ebola outbreak has been a lack of reliable information.
An operation called an episiotomy, which widens the birth canal to facilitate easier deliveries, seems to be on the decline in the United States, a new study indicates. …To assess current rates, study author Dr. Alexander Friedman and his colleagues at the Columbia University College of Physicians and Surgeons in New York City examined data on more than 2.2 million American women who had vaginal deliveries at 510 different facilities between 2006 and 2012. Overall, a little more than 14 percent underwent an episiotomy during that period, the researchers report in the Jan. 13 issue of JAMA. In 2006, about 17 percent of deliveries involved the surgery, compared to less than 12 percent in 2012, the study found.
The human health effects of low-dose radiation have long been a puzzle. “We know that high doses of radiation cause cancer,” says biophysicist David Brenner, director of Columbia University’s Center for Radiological Research, “but as you go down lower and lower in dose it becomes less and less clear what’s happening.” Detecting slight increases in cancer risk, for instance, is difficult. Some scientists have proposed that there is a threshold level, below which exposure to radiation is not dangerous, but there is no consensus on whether such a threshold exists, or what the safe exposure level would be, Brenner says.