Angela Christiano, a professor in the Departments of Dermatology and of Genetics and Development at Columbia who helped direct the research, is herself an alopecia patient. “Patients with alopecia areata are suffering profoundly, and these findings mark a significant step forward for them. The team is fully committed to advancing new therapies for patients with a vast unmet need,” she said.
After trying various treatments, Brian enrolled this year in a study at Columbia University Medical Center testing whether a drug approved for a bone marrow disorder could help people with alopecia. One of the study’s leaders, Angela Christiano, is a dermatology professor and geneticist who herself has alopecia areata.
Jeremiah Knowlton, 6, of Allendale, N.J., is the first patient in the New York area to undergo spinal-lengthening treatment with the fast-acting, noninvasive, painless MAGEC (MAGnetic Expansion Control) device.
Columbia University’s psychiatry chair Dr. Jeffrey Lieberman joins the “CBS This Morning” co-hosts to discuss effects of the comedic legend’s battles with depression, drugs, and alcohol.
The immune system destroys the insulin-producing cells in type one diabetics, but researchers at Columbia University Medical Center say it’s possible to teachgastrointestinal cells to make insulin by turning off a certain gene.
A doughnut created in a lab and made of silk on the outside and collagen gel where the jelly ought to be can mimic a basic function of brain tissue, scientists have found.
Not only are we doctors poorly educated in nutrition, but there is a serious absence of funding to properly answer some of the most important questions that all nutrition specialists are being asked. The result is an unremitting epidemic of obesity and a multitude of preventable nutrition-related diseases on the one hand, and “experts” promoting opinion as fact, guidelines that are moving targets, and a public expecting to be able to rely on nutritional supplements as magic cures on the other.
Until and unless the funding for very large, effective, long-term randomized studies of the effect of different diets on preventing disease becomes available, nutrition experts must educate themselves and the public about the strengths and weaknesses of the data on which their opinions are based.
“This is a tremendously important effort, tracking the course of war-related trauma from young adulthood past middle age — we have nothing else like this,” said Bruce Dohrenwend, a professor of epidemiology and social sciences at Columbia University who was not involved in the study. “Now, we need to dig in and figure out what these results mean.”
Through its Brain Research Apprenticeships (BRAINYAC), Columbia’s Mind Brain Behavior Institute gives high school students a chance to conduct brain research.
The threat in the developed world is minimal, and any infections that did occur could be easily isolated, says W. Ian Lipkin in a Wall Street Journal op-ed.
Chris Hayes talks to Dr. Stephen Morse, an expert in infectious diseases, about what’s preventing U.S. drug companies from developing an Ebola vaccine.
Life in the womb is much busier than you might expect, said Dr. Bill Fifer, a professor of psychiatry at Columbia University and a leading expert on fetal and newborn learning. “Everything that a newborn baby does, a fetus has pretty much done already,” Fifer said. “They’re exquisitely able to sense information over all parts of their body, although some are more sensitive than others, like around the mouth, around the feet, around the hands.”
National Geographic recently talked with W. Ian Lipkin, an expert in viral diseases and the John Snow Professor of Epidemiology at the Mailman School of Public Health at Columbia University, about why this outbreak is so much more widespread than previous ones.
Susan Koujak has a rare pulmonary vascular disease that caused both of her lungs to fail. During the last 12 years, she’s undergone two double lung transplants. Her first transplanted lungs began to fail last year and she received her second set of donor lungs in May. Both of her transplants were performed by the same talented team of doctors and nurses at NewYork-Presbyterian Hospital/Columbia University Medical Center.
As CBS 2′s Dr. Max Gomez explained, researchers [at Columbia University Medical Center] have succeeded in making insulin producing cells in other parts of the body.
Dr. Carl W. Bazil, a sleep disorders specialist at Columbia University, says A.S.M.R. videos may provide novel ways to switch off our brains. “People who have insomnia are in a hyper state of arousal,” he said. “Behavioral treatments — guided imagery, progressive relaxation, hypnosis and meditation — are meant to try to trick your unconscious into doing what you want it to do. A.S.M.R. videos seem to be a variation on finding ways to shut your brain down.”
Of those, 99 women had uterine cancer that was detected afterward. (If doctors had known about the cancer, they would not have used morcellation.) That means one in 368 women undergoing a hysterectomy had cancerous tumors that risked being spread by morcellation, said Dr. Jason D. Wright, the lead author and chief of gynecologic oncology at Columbia University College of Physicians and Surgeons.
The study, published by Columbia University doctors in the Journal of the American Medical Association, sheds new light on the potential hazards of a surgical tool called a power morcellator that is used to remove uterine growths, fibroids, in laparoscopic surgery. It also found that the device might spread a wider range of cancers than previously believed. …The authors chose to conduct the study because of recent publicity about the device, said Jason D. Wright, lead author and the director of gynecologic oncology at the Columbia University College of Physicians and Surgeons. Although power morcellators have been on the market for two decades, scant data existed about the tool, he said.
Current treatments for drug-resistant TB involve daily injections, sometimes for as long as six months, and can last as long as two years. The logistical challenge of the current long-term treatments for TB keep many from completing the full course, said Amrita Daftary, a postdoctoral fellow with ICAP, formerly the International Center for AIDS Care and Treatment Programs at Columbia University in New York. “If you’re suddenly cutting down that regimen to 6 months you’re probably going to see more people completing the treatment,” Daftary said by telephone. “It would be such a boon because it would reduce the stigma associated with TB.”
Albert James Stunkard was born in Manhattan on Feb. 7, 1922, the son of Horace Stunkard, a professor of biology at New York University, and Frances Klank Stunkard, a librarian. He received his bachelor’s degree from Yale in 1943 and his medical degree from Columbia in 1945 before serving as an Army physician in occupied Japan, where he became a student of Shunryu Suzuki, a Buddhist monk who later helped popularize Zen Buddhism in the United States.
[Laura] Erickson-Schroth is a fellow in public psychiatry and LGBT health at Columbia University Medical Center. She’s also a founding member of the Gender and Family Network of New York City. When she was in medical school at Dartmouth, she says, she met a lot of patients who were transgender. “I started to see that there were some patterns — there were people talking about this disconnect between trans communities and providers,” Erickson-Schroth says.
Dr. James M. McKiernan, interim chairman of the department of urology at Columbia, said the lack of a clear causal mechanism was a drawback of the new research. “If someone asked for a vasectomy, I would have to tell them that there is this new data in this regard, but it’s not enough for me to change the standard of care,” he said. “I would not say that you should avoid vasectomy.”
For the next six weeks, Eyewitness News will be taking you inside Manhattan’s New York-Presbyterian Hospital for a look at some extraordinary stories that we call Medical Marvels. It’s a web series exclusive to 7online. In part 1, you will meet Maureen Cavanaugh, who has struggled with her weight for years. She says she’s tried every type of diet and weight loss regimen imaginable. In March, she underwent a new procedure called an Endoscopic Sleeve Gastroplasty, performed by Dr. Marc Bessler at New York-Presbyterian/Columbia University Medical Center.
One expert who was not involved in the new study, Dr. James M. McKiernan, acting chairman of urology at NewYork-Presbyterian Hospital/Columbia University Medical Center said its findings were “eye-opening and even alarming.” “This isn’t the first study that suggests that there’s no added benefit to this therapy,” said Dr. McKiernan said. “But there are still a fair number of doctors recommending it and patients receiving it.”
This live-action experiment was conducted in early June by the Columbia University neuroscientist Daniel Salzman. His premise is that no event or object is ever experienced in perfect, objective isolation. It is instead subject to our past experiences, our current mood, our expectations, and any number of incidental details—an annoying neighbor, a waiter who keeps banging your chair, a beautiful painting in your line of sight. With something like wine, all sorts of societal and personal complications come into play, as well. We worry, for example, about whether our taste is “good.”
Smell is another area of interest because the odor center of the brain appears particularly vulnerable to Alzheimer’s pathology and the ability to identify different smells becomes impaired relatively early in the disease process. A study of some 1,000 individuals without Alzheimer’s diagnoses who were examined from 2004 to 2006, using a simple scratch-and-sniff smell test known as the UPSIT, showed that lower scores on the test were associated with a greater risk of developing Alzheimer’s—even if the individual was cognitively normal at the beginning of the study, said Davangere Devanand, a Columbia University psychology and psychiatry professor.
Two other studies looked at a smell test for Alzheimer’s. Again, early research has suggested that the disease can affect the olfactory centers of the brain. Dr. Davangere Devanand of Columbia University Medical Center in New York and colleagues tested 1,037 people in New York City, with an average age of 80. None had Alzheimer’s the first time they were seen in 2004-2006. They were seen again in 2006-2008 and 2008-2010. They took a standard smell test. “It’s a standardized test which has 40 items, each of which is a scratch-and-sniff item. The person smells it and has to choose the correct choice from four choices,” Devanand told NBC News. “All are very familiar smells, such as gasoline, pizza, tea, apple.”
In a similar study, Davangere Devanand, a professor of psychiatry at Columbia University Medical Center, and colleagues administered the same University of Pennsylvania odor-detection test on 1,037 healthy, elderly people several times over a longer period of time. His team also found some correlation between declining sense of smell and the transition from mild cognitive impairment to dementia: Of those who took part, 757 people who scored lower on tests of their sense of smell also showed a decline from mild cognitive impairment to dementia and Alzheimer’s.
Cardiac surgery appealed to me because it was a chance to make a real, measurable impact on the lives of people every single day, helping people out of literally life-threatening situations. As much as I enjoy this, it is the impact that these operations have on their extended families that is most gratifying.
Michael Argenziano, M.D., is Chief of Adult Cardiac Surgery at New York-Presbyterian Hospital/Columbia University Medical Center, where he is also Director of Minimally Invasive Cardiac Surgery and Program Director of the Residency in Thoracic Surgery. He received his M.D. from the Columbia University College of Physicians and Surgeons, and completed his training in cardiothoracic surgery, mechanical cardiac assistance, and surgical electrophysiology, all at NewYork-Presbyterian Hospital.
The campaign, which draws upon anti-obesity research conducted at Columbia University Medical Center, seeks to make healthy eating seem cool through original hip-hop songs, comic books and cartoon-style videos. “It’s about having fun while learning,” said Dr. Olajide Williams, a Nigerian-born neurologist at the medical center and at NewYork-Presbyterian Hospital, who founded Hip Hop Public Health. “Their minds are unlocked by the entertainment and then we can input the knowledge and skills they need to learn.”
Dr. David Rothman is a professor of social medicine and history and the director of the Center for the Study of Society and Medicine at the College of Physicians and Surgeons at Columbia University.
“Diagnostic language is used among doctors to describe features of a mental illness,” said Dr. Brian K. Clinton, an assistant professor at Columbia University Medical Center who has written about sharing records. “I would be willing to discuss with a patient what I think. It’s a better way to communicate than a note I wrote for other doctors.”
Other novel ideas to keep people in treatment are currently in testing. Dr. Wafaa El-Sadr, director of the International Center for AIDS Care and Treatment Programs at Columbia, is running a trial of a program that makes cash payments to patients with H.I.V. in exchange for quarterly tests showing undetectable viral loads.
“I would like women to see this ACP recommendation as good news,” said Dr. Carolyn Westhoff, a professor of obstetrics and gynecology at Columbia University Medical Center. “In a person with no complaints, is it worth doing anything to them?”
Three days before the F.D.A. hearing, I called a scientist who would be making a presentation there, Dieter Egli, of the New York Stem Cell Foundation [and Columbia University Medical Center], and asked him what he thought the stakes were. Egli is Swiss, and he speaks an accented English both blunt and elegant. He said his goal was to use cells to cure disease, because we are made of cells: tiny, complex, independent ecosystems. Eggs are single cells — the largest ones in the human body — and to him, replacing their mitochondria, then putting them back into women safely and successfully, is like beginner cell therapy. …In 2008, Egli moved from Harvard to the New York Stem Cell Foundation, a nonprofit group and one of only a handful of privately funded stem-cell laboratories in the country, to continue his work. Two years later, Michio Hirano, a mitochondrial specialist at Columbia, approached Egli to see if he might be able to help his patients.
The method, described today in the journal Nature Communications, raises the possibility of replacing insulin-making pancreatic beta cells lost in diabetics by using a drug to retrain patients’ existing cells. While progress has been made in generating beta cells from stem cells, the method hasn’t yet produced ones with all the needed functions, said Domenico Accili, the study’s lead author. Plus, such cells would require transplantation. “We provided a proof of principle that we can do this in human tissues and are also very excited that there is a single identifiable target to trigger this process,” Accili, professor of medicine at Columbia University’s Naomi Berrie Diabetes Research Center in New York, said in an interview.
The ensuing enthusiasm led to a medical trial in the seventies with the goal to test whether patients with lung failure did better with ECMO or with a respirator alone. In both groups, more than ninety per cent of patients died. The excitement about ECMO for adults with lung failure “fell back to earth,” Daniel Brodie, who directs the medical ECMO program at Columbia University Medical Center, told me. But in the ensuing decades, ECMO technology grew more sophisticated. The machine was smaller, complications fewer. In the late aughts, Brodie started to talk to his colleagues about whether ECMO could help patients with respiratory failure. “Enthusiasm for ECMO was—to put it mildly—in short supply,” Brodie said. “People essentially fell into two camps: agnostic and dead set against.”
A clinical cancer whole-exome and transcriptome sequencing test recently launched by Columbia University’s Laboratory of Personalized Genomic Medicine promises to impact the treatment of cancer patients. The new test was developed as part of a wider effort to incorporate personalized medicine approaches into Columbia’s pediatric oncology program, according to Andrew Kung, chief of the division of pediatric hematology, oncology, and stem cell transplantation.
It’s a common sign of aging. By the time we reach 65, it is estimated that half the population will have a cataract, and all of us will likely have one by 75. Dr. Leejee Han Suh is an ophthalmologist at NewYork-Presbyterian Columbia University Medical Center. “A cataract is a cloudiness in the lens in your eye and it can cause progressive vision changes and ultimately a decrease in your vision.” She says cataracts are part of the aging process.
There’s a growing evidence for the health benefits of good posture, from reducing back and joint pain to boosting mood. WSJ’s Jeanne Whalen and NY-Presbyterian/Columbia University Medical Center’s Dr. Evan Johnson discuss on Lunch Break with Tanya Rivero.
Today, [Dr. Anne Taylor]‘s playing the cello again—as a member of the Adelphi Orchestra in River Edge, N.J. Forty of the group’s 50 members, including Dr. Taylor, are over age 50. She squeezes in practice and rehearsals around her job as a cardiologist and vice dean for academic affairs at Columbia University College of Physicians and Surgeons in New York.
Because the chemical method is less studied, “it would have been prudent to handle the samples as if they were live organisms,” said Stephen Morse of the Columbia University Institutional Biosafety Committee and former program manager for biodefense at the Pentagon’s Defense Advanced Research Projects Agency (DARPA).
Rhythmic sequences are also required to move around, says Mark Churchland, a brain scientist at Columbia University. Walking, for example, requires repeatedly lifting a foot up, putting it down, and pushing it back. Fish swish a tail from side to side to swim. “It’s sort of hard to imagine any way of doing continuous locomotion that wasn’t built on a rhythmic underpinning,” Churchland says.
New York-Presbyterian/Columbia University Medical Center: Dr. William Levine, 49, was appointed chair of the Department of Orthopedic Surgery at the Columbia University College of Physicians and Surgeons and orthopedic surgeon in chief at the academic medical center, effective July 1. He previously was the department’s vice chair for education, director of its residency and fellowship programs, chief of the shoulder service, and co-director of the Center for Shoulder, Elbow & Sports Medicine.
The study suggests high levels of saturated fat alter the composition of arterial cells, allowing white blood cells linked to atherosclerosis called macrophages to accumulate. Lab experiments at Columbia University in New York involved five groups of mice. One group was fed a standard diet with only saturated fat, while another had a diet with only omega-3s. Two groups received a combination of saturated fat and either 25% or 50% omega-3s in their diets. Control mice had a low-fat diet.
A complex interplay of genes, stress and hormones causes maternal mental illness, scientists say. “Hormones go up more than a hundredfold,” said Dr. Margaret Spinelli, the director of the Women’s Program in Columbia University’s psychiatry department. After birth, hormones plummet, a roller coaster that can “disrupt brain chemistry,” she said.
“This paper is an interesting example of how important it is for cancer patients to be treated by experienced surgeons and in higher volume institutions,” said Dr. Dawn L. Hershman, leader of the Breast Cancer Program at the Herbert Irving Comprehensive Cancer Center of Columbia University Medical Center in New York. Hershman was not a part of the new study.